OpenTox USA 2013
OpenTox InterAction Meeting
Innovation in Predictive Toxicology
Open Infrastructure and Application Development, Integrated Data Analysis, Biokinetics
Cheminformatics, Bioinformatics, Weight of Evidence, Risk Assessment
Organised in Collaboration with ToxBank
29 - 30 October 2013
Hamner Conference Center, North Carolina Biotechnology Center, Raleigh-Durham, USA
This meeting will discussed latest developments in predictive toxicology, including in silico modelling and application development, integrated data analysis, biokinetics, cheminformatics, bioinformatics, weight of evidence and risk assessment. Discussions will include consideration of current research and development directions in addition to risk assessment and regulatory and industry needs.
Organising Committee
The meeting will be co-chaired by Barry Hardy (Douglas Connect), Scott Auerbach (NIEHS), Rusty Thomas (US EPA), and Asish Mohapatra (Health Canada).
Abstract Submission
Abstracts should be submitted through the conference Easy Chair
system and will be reviewed by the organising
committee. The program will consist of both invited and submitted
presentations, with all abstracts subject to review. Accepted abstracts
will be included as either presentations in the conference sessions
and/or poster session. Abstracts should be 200-500 words in length and
should be submitted at the latest by 30 September 2013 for inclusion in the poster session. The final conference
program will be announced by 31 August 2013. Please submit your abstracts
using the form located at:
https://www.easychair.org/conferences/?conf=opentoxusa2013
Poster Session
Posters loaded upon poster boards will be available throughout the conference. Presenters are also welcome to demonstrate novel methods and software. All posters will be reviewed at the meeting to provide presenters feedback. Awards for best posters and most innovative software will be announced in the final meeting session.Location
The meeting will be held at the Hamner Conference Center, North Carolina Biotechnology Center located in Research Triangle Park, North Carolina, USA (www.ncbiotech.org). You can view a google map showing the location of the center and nearby hotels at:
Registration
Places are limited so please complete the registration form to reserve a place at the meeting:
https://www.surveymonkey.com/s/OpenToxUSA2013
Registration payment ($100): events2.douglasconnect.com/?q=OTUS13
Conference Program
For Detailed Speaker Program with Abstracts: View OpenTox USA 2013 Speaker Program (http://www.opentox.org/meet/opentoxusa2013/opentoxusa2013speakerprogram/)
A. The Data Foundation for Predictive Toxicology, chaired by Scott Auerbach (NIEHS)
OpenTox - Development of Open Standards, Open Source and Open Data supporting Predictive Toxicology, Barry Hardy (Douglas Connect) (see presentation PDF)
The NTP DrugMatrix Database, Scott Auerbach (NIEHS) (see presentation PDF)
ToxRefDb, Matt Martin (US EPA)
The CEBS Database, a Structure for Data Integration across Studies, Asif Rashid (NIEHS) (see presentation PDF)
Implementation of Systematic Review, Kristina Thayer (NTP) (see presentation PDF)
The COSMOS Database, Chihae Yang (Altamira)
B. Development and Application of Predictive Toxicology Models, chaired by Barry Hardy (Douglas Connect)
Evidence-based toxicology - the toolbox for quality assurance of Tox-21c tools, Thomas Hartung (John Hopkins) (see presentation PDF)
Supporting an Integrated Data Analysis across SEURAT-1 through the ToxBank Data Warehouse, Glenn Myatt (Leadscope) (see presentation PDF)
Creation of microfluidic bioreactor to assess in vitro long-term fibrogenic toxicity of drugs and cosmetics on liver, Pau Sancho-Bru (Institut d’Investigacions Biomèdiques August Pi i Suyner)
Advanced Multi-Label Classification Methods for the Prediction of ToxCast Endpoints, Stefan Kramer (Johannes Gutenberg University of Mainz)
Complementary PLS and KNN algorithms for improved 3D-QSDAR consensus modeling of AhR binding and other toxicological endpoints, Richard Beger (US FDA)
C. Extrapolation and Integration of Predictive Toxicology Models,
chaired by Rusty Thomas (US EPA)
In Vitro and In Vivo Extrapolation in Predictive Toxicology, Harvey Clewell (Hamner Institute) (see presentation PDF)
High Throughput Human Exposure Forecasts for Environmental Chemical Risk, John Wambaugh (US EPA) (see presentation PDF)
HAWC (Health Assessment Workspace Collaborative): a modular web-based interface to facilitate development of human health assessments of chemicals, Ivan Rusyn (UNC) (see presentation PDF)
Multi-scale data integration and modeling, Tom Knudsen (US EPA) (see presentation PDF)
D. Application of Predictive Toxicology in Risk Assessment, chaired by Asish Mohapatra (Health Canada)
From bench to FDA, validation of in vitro methods: who is responsible for independent validation of human biology-based tests? Katya Tsaioun (Safer Medicines Trust) (see presentation PDF)
In Silico Models for Screening New Drugs for QT Prolongation Potential using Human Clinical Trial Data, Luis G. Valerio, Jr (US FDA) and Kevin Cross (Leadscope) (see presentation PDF)
The (U.S.) National Library of Medicine: Collecting, Organizing, and Disseminating Information in Toxicology, Exposure Science, and Risk Assessment, Pertti Hakkinen (NIH) (see presentation PDF)
Application of Predictive Tools to Environmental Assessment and Remediation, Asish Mohapatra (Health Canada) and Barry Hardy (Douglas Connect) (see presentation PDF)
HESI’s RISK21 Project: A Tiered and Transparent Human Health Risk Assessment System for the 21st Century, Tim Pastoor (Syngenta)
Knowledge Café
Participants will discuss the predictive toxicology topics in small groups.
Schedule
Monday, October 28
Pre-Conference Technical Meeting on OpenTox Open Standards
14:00 - Welcome
14:15 - OpenTox API Needs (short 5 minutes summaries)
14:45 - OpenTox API Discussions
15:30 - Coffee break
16:00 - OpenTox API Discussions & Decisions
18:00 - End
Tuesday, October 29
08:00 - Registration opens
08.45 - Chair's Welcome
09:00 - Section A. The Data Foundation for Predictive Toxicology, chaired by Scott Auerbach (NIEHS)
10:30 - Coffee break
12:00 - Section B. Development and Application of Predictive Toxicology Models, chaired by Barry Hardy (Douglas Connect)
13:00 - Lunch
14.00 - Section B. Development and Application of Predictive Toxicology Models, chaired by Barry Hardy (Douglas Connect)
15.00 - Knowledge Café discussions (Data, Models)
16:30 - Poster session
Wednesday, October 30
09:00 - Section C. Extrapolation and Integration of Predictive Toxicology Models, chaired by Rusty Thomas (US EPA)
11:00 - Coffee break
11:30 - Section D. Application of Predictive Toxicology in Risk Assessment, chaired by Asish Mohapatra (Health Canada)
12:30 - Lunch
13:30 - Section D. Application of Predictive Toxicology in Risk Assessment, chaired by Asish Mohapatra (Health Canada)
14:30 - Knowledge Café Discussions (Extrapolation, Risk Assessment)
16:00 - Panel Discussion
16.45 - Conclusions and Best Poster/Software Awards
17.00 - Close of Meeting
