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Adverse Outcome Pathway (AOP) building with the AOP Knowledge Base

Clemens Wittwehr (EU Joint Research Centre)

In this tutorial you will learn how Adverse Outcome Pathways (AOPs) can be captured with the AOP Knowledge Base (AOP-KB). An AOP is an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. AOPs are the central element of a toxicological knowledge framework being built to support chemical risk assessment based on mechanistic reasoning. The AOP-KB is the tool that OECD develops and endorses to use for global knowledge sharing and synergy exploitation.

General Information / Requirements

Description of Activity:

In this tutorial you will:

  • see a short introduction to what AOP-KB is all about, especially its connection to the relevant OECD guidance (see below),
  • be briefed about how AOP thinking maps to the data model of AOP-KB,
  • see a walk-through of the actual AOP-KB; the hands-on example used will be the Liver Fibrosis AOP.


Recommended reading before the event:

The AOP-KB implements the OECD "Guidance Document on Developing ond Assessing Adverse Outcome Pathways"; to fully profit from the session, it is recommended to browse through guidance before:

Part I of the document gives the theoretical background; Part II is the actual description of the template to capture AOP knowledge. This template is implemented in the AOP-KB.


Required Software:

None. Please note that the AOP-KB is not yet publicly available; what you will see is the currently restricted version which will be launched officially in December 2013.

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