Sections
Reading Room
 
You are here: Home » Home » Reading Room » Presentations

Presentations

Presentations related to OpenTox

File Collaborative Development of Predictive Toxicology Applications
The CMTPI 2009 Plenary Lecture "Collaborative Development of Predictive Toxicology Applications" was presented by OpenTox Coordinator Barry Hardy (Douglas Connect) in Istanbul on 6 July 2009 at the Fifth International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI 2009).
File Initial OpenTox Evaluation of ToxCast Phase 1 Datasets
Barry Hardy (Douglas Connect) presented a seminar “Initial OpenTox Evaluation of ToxCast Phase 1 Datasets” at the US EPA ToxCast data summit, held at the U.S. EPA National Center for Computational Toxicology, EPA Campus, Research Triangle Park NC, USA, 14-15 May 2009, describing the initial preliminary analysis of the Toxcast phase 1 dataset by OpenTox partners.
File Hierarchical Multi-label Classification of ToxCast Datasets
Nina Jeliazkova (Ideaconsult) presented a seminar “Hierarchical Multi-label Classification of ToxCast Datasets” at the the US EPA ToxCast data summit 14-15 May 2009.
File Preliminary Evaluation of ToxCast™ Phase 1: Sketching the Landscape
Poster by Romualdo Benigni, Cecilia Bossa, and Alessandro Giuliani (ISS) presented at the US EPA ToxCast data summit 14-15 May 2009.
File (Q)SAR and (Q)AAR analysis of ToxCast Dataset Using PASS and GUSAR approaches
Poster by Vladimir Poroikov, Dmitry Filimonov, Alexey Zakharov, Alexey Lagunin, and Sergey Novikov (IBMC) presented at the US EPA ToxCast data summit 14-15 May 2009.
File Large-Scale Graph Mining Using Backbone Refinement Classes
The paper “Large-Scale Graph Mining Using Backbone Refinement Classes” by Andreas Maunz (ALU), Stefan Kramer (TUM) and Christoph Helma (IST) was presented by Andreas Maunz at KDD 2009.
File Integrated Predictive Toxicology Application Development
This presentation reviews the philosophy, issues, design, and implementation of integrated predictive toxicology applications as pursued within the OpenTox Framework and was presented by OpenTox Coordinator Barry Hardy at the EMBL-EBI Industry Program Workshop on Toxicogenomics & Toxicoinformatics, 23 November 2009, Hinxton, UK.
File Predictive Toxicology Applications - Regulatory, Transparency, and Interoperablity Requirements
An invited seminar on OpenTox developments titled "Advances in Predictive Toxicology Applications Satisfying Regulatory, Transparency, and Interoperablity Requirements" was delivered by Barry Hardy (Douglas Connect, OpenTox Project Coordinator) at the Mondial Research Group conference on Predictive Human Toxicity and ADME/Tox Studies, held January 28th - 29th, 2010 in Brussels, Belgium. The program covered a number of emerging topics and advances in predictive ADME/tox taking place in the pharmaceutical industry (http://www.mondialresearchgroup.com/index.php?whereTo=humt10). A copy of the presentation is provided here as a pdf download.
File OpenTox - an Open Source Predictive Toxicology Software Framework
OpenTox seminar presented at the 239th ACS Meeting, San Francisco, 25 March 2010.
File Integrating Predictive Toxicology Applications and Resources
OpenTox presentation, OpenTox Workshop, Potsdam, 30 May 2010
File Integrating Predictive Toxicology Model Development
OpenTox Presentation delivered by Barry Hardy at the SMi conference on "ADMET - Translating Research into Clinical Outcomes", 7-8 July 2010, Crowne Plaza Hotel, London, UK
File OpenTox Applications
OpenTox Presentation delivered by Nina Jeliazkova at the SMi conference on "ADMET - Translating Research into Clinical Outcomes", 7-8 July 2010, Crowne Plaza Hotel, London, UK
File Satisfying REACH requirements in predictive toxicology
Invited presentation delivered by Barry Hardy at the "Accomplishments & Challenges in Global Chemicals Policy" session at the IUTOX 2010 conference, 22 July 2010, Barcelona, Spain. Abstract: Satisfying REACH Requirements in Predictive Toxicology Barry Hardy, OpenTox Project Coordinator, Douglas Connect, Baermeggenweg 14, 4314 Zeiningen, Switzerland. Tel: +41 61 851 0170. Email: Barry.Hardy _(at)- douglasconnect.com The REACH legislation put in place a regulatory framework for the most extensive evaluation of the safety of chemicals that has ever been undertaken. Over 142,000 chemical entities have already been registered that may be subject to assessment in coming years. Any organisation involved in the manufacture or import of any chemical at levels over 1 ton/annum into the European marketplace is affected. We will discuss the impacts of this legislation on industry and its economic impacts. How will both large and small companies cope with satisfying REACH requirements? New methods based on computer-based approaches and emerging research areas in chemistry and biology provide alternatives to traditional animal experiments and are included in the REACH chemical safety guidelines. When will the outputs from this research be available for deployment by industry for REACH purposes? In addition to new R&D methods, there is a strong need for coordination between programs and resources. Progress on a well-engineered modernization of predictive toxicology information technology and interoperability between toxicology systems and resources is urgently required. The OpenTox Framework (1) has been developed to support the communication between toxicology resources, based on standard representations of data, and the ability for distributed resources to exchange that data, build and validate models, and generate report information relevant for REACH. We will discuss the approach of OpenTox and related developments and initiatives, current challenges and future directions, including the need and benefits for collaborative approaches and the infrastructure requirements for supporting interdisciplinary science. (1) OpenTox - An Open Source Predictive Toxicology Framework, is funded under the EU Seventh Framework Program: HEALTH-2007-1.3-3 Promotion, development, validation, acceptance and implementation of QSARs (Quantitative Structure-Activity Relationships) for toxicology, Project Reference Number Health-F5-2008-200787 (2008-2011). More information at www.opentox.org
File Development and Use of Predictive Toxicology Applications
Presentation slides used by Barry Hardy, Christoph Helma, Nina Jeliazkova, Olga Tcheremenskaia, Stefan Kramer, Haralambos Sarimveis and Andreas Karwath on their presentation of the OpenTox Framework at the OpenTox workshop held 19 September 2010, Rodos Palace Hotel, Rhodes, Greece (See program and activities summary at http://www.opentox.org/data/blogentries/public/opentoxworkshoprhodes2010)
File Development and Use of Predictive Toxicology Applications
Presentation by Barry Hardy at the Biomedical Research Centre, University of Uppsala, 19 October 2010.
File Directions for Integrated Analysis in Predictive Toxicology
Presentation by OpenTox Coordinator Barry Hardy, PathProt 3, 21 October 2010, IGC, Oeiras, Portugal. (final slides summarise some discussion topics on extending the predictive toxicology framework to include infrastructure for supporting pathways-based strategies, omics data analysis and systems biology modelling)
File Ontology Development in support of Predictive Toxicology Use Cases & Services
presented by OpenTox Coordinator Barry Hardy (Douglas Connect) at the OpenTox-EBI Industry forum workshop on Toxicology Ontology held at the EMBL-EBI campus, Hinxton, Cambridge, UK, 15-17 November 2010.
File Insights into an Interoperable Approach to Collaborative Drug Design and Predictive Toxicology
Presentation on Interoperable Infrastructure Approach to Collaborative Drug Design and Predictive Toxicology 24 February 2011 IQPC Predictive Toxicology Conference, London, UK by Barry Hardy (Douglas Connect) Barry.Hardy -(at)- DouglasConnect.com
File OpenTox: An open source web service platform for toxicity prediction
OpenTox talk presented by David Gallagher and Sunil Chawla, at the ACS Spring 2011 meeting session on the Internet & Chemistry in Anaheim, 30th March 2011
Link Collaborative Virtual Organisation and Infrastructure for Anti-Malarial Drug Design (Presentation)
Presentation presented by OpenTox Coordinator, Barry Hardy at the BIO-IT 2011 conference in Boston, 13 April 2011, in the Collaborative Drug Design session. OpenTox will contribute to the Scientists Against Malaria initiative through the holistic incorporation of predictive toxicology modelling of drug design libraries.
Link Collaborative Virtual Organisation and Infrastructure for Anti-Malarial Drug Design (Poster)
Poster presented by OpenTox Coordinator, Barry Hardy at the BIO-IT 2011 conference in Boston, 12-14 April 2011. OpenTox will contribute to the Scientists Against Malaria initiative through the holistic incorporation of predictive toxicology modelling of drug design libraries.
Link OpenTox - An Open Interoperable Predictive Toxicology Framework
Slides presented by OpenTox Coordinator, Barry Hardy at the BIO-IT 2011 conference in Boston, 12 April 2011, at the workshop session on Current Methods for Computational Toxicology and Chemogenomics. The presentation includes developments on numerous applications (built upon OpenTox APIs and web services) including ToxCreate, ToxPredict, Bioclipse, Qedit, Ches-Mapper, and integration with other initiatives such as CDK, ToxML, and ToxCast.
Link OpenTox Services and Applications
Presentation of recent developments in OpenTox services and applications, presented by Barry Hardy at the AXLR8 meeting in Berlin, 23 May 2011
File Collaborative Virtual Organisation and Infrastructure for Anti-Malarial Drug Design
Presentation by Barry Hardy at the BIO-IT Europe 2011 conference in Hannover, 12 October 2011, in the Collaborative Drug Design program. OpenTox is contributing to the Scientists Against Malaria initiative through the holistic incorporation of predictive toxicology modelling of drug design libraries using weight of evidence–based workflows across public and commercial resources.
Document Actions