OpenTox Ontology
The goal of OpenTox is to develop an interoperable predictive toxicology framework with multiple web services providing users access to distributed toxicological resources including data, computer models, validation and reporting. OpenTox applications are based on use cases that satisfy user needs in predictive toxicology. The definition of ontology and controlled vocabulary is extremely important to the construction of the OpenTox data infrastructure. It contributes to the necessary standardization and rational organization of data, describing and linking toxicological endpoints information in a formal way, suitable for being processed automatically by the software, with minimal human interaction.
Besides a ontology for toxicological endpoints and Organs and Effects Ontology, a formal OWL representation of modeling algorithms is available on the OpenTox website http://www.opentox.org/dev/apis/api-1.1/Algorithms.
The collaborative work on the project is curated using the Collaborative Protégé Editor Collaborative Protege, with different access privileges . The ontology is open for community reviews and annotations.
References:
OpenTox Predictive Toxicology Framework: toxicological ontology and semantic media wiki-based OpenToxipedia, Bio-ontologies 2011. 15-16 July, Vienna, Austria
Bio-ontology 2011_slides.pdf
OpenTox-Bio-ontologies_2011_article.pdf
Collaborative Ontology Design and Implementation for the OpenTox Predictive Toxicology Framework, Bio-ontologies 2010, 9-10 July, Boston MA
Poster: Collaborative Ontology Design and Implementation for the Open- Tox Predictive Toxicology Framework
Abstract: Collaborative Ontology Design and Implementation for the Open- Tox Predictive Toxicology Framework
